which the corruption of the church had been foulest, but from which all symptoms of "heretical pravity" were purged away with the fiercest zeal as fast as they appeared,--in Spain under the reign of Ferdinand and Isabella the Catholic,--that the demand for a Catholic reformation made itself earliest and most effectually felt. The highest ecclesiastical dignitary of the realm, Ximenes, confessor to the queen, Archbishop of Toledo, and cardinal, was himself the leader of reform. No changes in the rest of Christendom were destined for many years to have so great an influence on the course of evangelization in North America as those which affected the church of Spain; and of these by far the most important in their bearing on the early course of Christianity in America were, first, the purifying and quickening of the miserably decayed and corrupted mendicant orders,--ever the most effective arm in the missionary service of the Latin Church,--and, a little later, the founding of the Society of Jesus, with its immense potency for good and for evil. At the same time the court of Rome, sobered in some measure, by the perilous crisis that confronted it, from its long orgy of simony, nepotism, and sensuality, began to find time and thought for spiritual duties. The establishment of the "congregations" or administrative boards, and especially of the _Congregatio de Propaganda Fide_, or board of missions, dates chiefly from the sixteenth century. The revived interest in theological study incident to the general spiritual quickening gave the church, as the result of the labors of the Council of Trent, a well-defined body of doctrine, which nevertheless was not so narrowly defined as to preclude differences and debates among the diverse sects of the clergy, by whose competitions and antagonisms the progress of missions both in Christian and in heathen lands was destined to be so seriously affected. An incident of the Catholic Reformation of the sixteenth century--inevitable incident, doubtless, in that age, but none the less deplorable--was the engendering or intensifying of that cruel and ferocious form of fanaticism which is defined as the combination of religious emotion with the malignant passions. The tendency to fanaticism is one of the perils attendant on the deep stirring of religious feeling at any time; it was especially attendant on the religious agitations of that period; but most of all it was in Spain, where, of all the Catholic nations, corruption had gone deepest and spiritual revival was most earnest and sincere, that the manifestations of fanaticism were most shocking. Ferdinand and Isabella the Catholic were distinguished alike by their piety and their part in the promotion of civilization, and by the horrors of bloody cruelty perpetrated by their authority and that of the church, at the instigation of the sincere and devout reformer Ximenes. In the memorable year 1492 was inaugurated the fiercest work of the Spanish Inquisition, concerning which, speaking of her own part in it, the pious Isabella was able afterward to say, "For the love of Christ and of his virgin mother I have caused great misery, and have depopulated towns and districts, provinces and kingdoms." The earlier pages of American church history will not be intelligently