the body. "From this distribution of blood in these minute vessels," he says, "the structure of organs derive their constituent parts; through these vessels brain matter, muscle, gland, membrane, are given out from the blood by a refined process of selection of material, which, up to this time, is only so far understood as to enable us to say that it exists. The minute and intermediate vessels are more intimately connected than any other part with the construction and with the function of the living matter of which the body is composed. Think you that this mechanism is left uncontrolled? No; the vessels, small as they are, are under distinct control. Infinitely refined in structure, they nevertheless have the power of contraction and dilatation, which power is governed by nervous action of a special kind." Now, there are certain chemical agents, which, by their action on the nerves, have the power to paralyze and relax these minute blood-vessels, at their extreme points. "The whole series of nitrates," says Dr. Richardson, "possess this power; ether possesses it; but the great point I wish to bring forth is, that the substance we are specially dealing with, alcohol, possesses the self-same power. By this influence it produces all those peculiar effects which in every-day life are so frequently illustrated." PARALYZES THE MINUTE BLOOD-VESSELS. It paralyzes the minute blood-vessels, and allows them to become dilated with the flowing blood. "If you attend a large dinner party, you will observe, after the first few courses, when the wine is beginning to circulate, a progressive change in some of those about you who have taken wine. The face begins to get flushed, the eye brightens, and the murmur of conversation becomes loud. What is the reason of that flushing of the countenance? It is the same as the flush from blushing, or from the reaction of cold, or from the nitrite of amyl. It is the dilatation of vessels following upon the reduction of nervous control, which reduction has been induced by the alcohol. In a word, the first stage, the stage of vascular excitement from alcohol, has been established." HEART DISTURBANCE. "The action of the alcohol extending so far does not stop there. With the disturbance of power in the extreme vessels, more disturbance is set up in other organs, and the first organ that shares in it is the heart. With each beat of the heart a certain degree of resistance is offered by the vessels when their nervous supply is perfect, and the stroke of the heart is moderated in respect both to tension and to time. But when the vessels are rendered relaxed, the resistance is removed, the heart begins to run quicker, like a watch from which the pallets have been removed, and the heart-stroke, losing nothing in force, is greatly