had begun to germinate; a blind impulse led the doomed individual, by successive and rapid strides, along the same course which was fatal to the father, and which, ere long, terminated in his own destruction." How great and fearful the power of an appetite which cannot only enslave and curse the man over which it gains control, but send its malign influence down to the second and third and fourth generations, sometimes to the absolute EXTINGUISHMENT OF FAMILIES! Morel, a Frenchman, gives the following as the result of his observation of the hereditary effects of drunkenness: "_First generation_: Immorality, depravity, excess in the use of alcoholic liquors, moral debasement. _Second generation_: Hereditary drunkenness, paroxysms of mania, general paralysis. _Third generation_: Sobriety, hypochondria, melancholy, systematic ideas of being persecuted, homicidal tendencies. _Fourth generation_: Intelligence slightly developed, first accessions of mania at sixteen years of age, stupidity, subsequent idiocy and probable extinction of family." Dr. T.D. Crothers, in an analysis of the hundred cases of inebriety received at the New York Inebriate Asylum, gives this result: "Inebriety inherited direct from parents was traced in twenty-one cases. In eleven of these the father drank alone, in six instances the mother drank, and in four cases both parents drank. "In thirty-three cases inebriety was traced to ancestors more remote, as grandfather, grandmother, etc., etc., the collateral branches exhibiting both inebriety and insanity. In some instances a whole generation had been passed over, and the disorders of the grandparents appeared again. "In twenty cases various neurosal disorders had been prominent in the family and its branches, of which neuralgia, chorea, hysteria, eccentricity, mania, epilepsy and inebriety, were most common. "In some cases, a wonderful periodicity in the outbreak of these disorders was manifested. "For instance, in one family, for two generations, inebriety appeared in seven out of twelve members, after they had passed forty, and ended fatally within ten years. In another, hysteria, chorea, epilepsy and mania, with drunkenness, came on soon after puberty, and seemed to deflect to other disorders, or exhaust itself before middle life. This occurred in eight out of fourteen, extending over two generations. In another instance, the descendants of three generations, and many of the collateral branches, developed inebriety, mental eccentricities, with other disorders bordering on mania, at about thirty-five years of age. In some cases this lasted only a few years, in others a lifetime."